Proteome Mapping Group

The Protein map Group is part of a multidisciplinary squad of biochemists, microbiologists, molecular biologists, and morphologic biologists inside the Biosciences section at Argonne National Laboratory (ANL). The Group uses planar gel electrophoresis (2DE) joined with computerized image and information analysis to qualify normal protein expression and to discover adapted protein expression in biological systems responding to environmental or pathologic stresses. Changes in the abundance or position of proteins in the 2DE patterns that correlate with exogenic pressures indicate the engagement of those proteins in the biological reaction chemical mechanism. designation of such proteins by using peptide mass mapping provides markers of biological response as well as keys to biochemical mechanisms related to detoxification of harmful chemicals, cellular reaction to metabolous stress, and dedication to distinction or programmed cell death. The efforts of the Protein Mapping Group are presently focused on analysis of proteins from microbial systems of concern to the U.S. Department of Energy. information from anterior studies of mouse and human cell systems are also useable.